• Aurora A overexpression is also related to the activation of

  2024-09-26

  

  Aurora-A overexpression is also related to the activation of NF-κB, a potent anti-apoptotic effector that may play a role in preventing apoptosis in cancer Guanethidine Sulfate [18]. These data show that we are still at the beginning of unraveling the complex mechanism by which these gene products

• Along with the improvement of the cadmium

  2024-09-26

  

  Along with the improvement of the cadmium transport from roots to aerial tissues, as is required for phytoremediation, over-expression of PtoHMA5 also led to the excessive accumulation of cadmium in leaves that was harmful to plant growth and physiological performance. Thus, detoxification of the he

• br Author contributions br Acknowledgments TJC KW and

  2024-09-25

  

  Author contributions Acknowledgments TJC, KW, and VG are supported by awards made to MJN: a Consolidator Grant from the European Research Council under Grant no. 311336; a University Research Fellowship from the Royal Society, and a Career Development Award from the Human Frontiers Science Pro

• In vascular endothelial cells L arginine produces nitric oxi

  2024-09-25

  

  In vascular endothelial cells, L-arginine produces nitric oxide (NO) under the action of nitric oxide synthase (NOS), and nitric oxide can activate guanylate cyclase to produce a large amount of cGMP, thereby relaxing vascular smooth muscle and expanding blood vessels. Numerous studies have confirme

• br Conflict of interest br Acknowledgements

  2024-09-25

  

  Conflict of interest Acknowledgements Introduction The mitogen-activated protein kinase (MAPK) pathway is an important intracellular signaling system that regulates diverse cellular functions, such as proliferation, differentiation, and apoptosis [1]. Apoptosis signal-regulating kinase 1 (A

• br Conclusion br Acknowledgments The

  2024-09-25

  

  Conclusion Acknowledgments The authors extend their appreciation to Kayyali Chair for Pharmaceutical Industry, Department of Pharmaceutics, College of Pharmacy, King Saud University for funding this work through the research project Number (G-2016-2). Introduction L-ornithine is a natural

• br Introduction Breast cancer is the second most lethal canc

  2024-09-25

  

  Introduction Breast cancer is the second most lethal cancer among women, accounting for approximately 40,000 deaths in the United States in 2015 [1]. The prognosis of breast cancer has improved significantly with the identification of immunohistochemical subtypes that predict response to therapy

• In human epidermoid carcinoma A cells lipoxygenase was

  2024-09-25

  

  In human epidermoid carcinoma A431 cells, 12-lipoxygenase was significantly increased in glutathione-depleted cells. The relative abundance of phospholipid hydroperoxide versus glutathione peroxidase seems to play an important role in controlling the lipoxygenase reaction [57]. It has been proposed

• HsALDH enzyme has been purified for the first

  2024-09-25

  

  HsALDH enzyme has been purified for the first time in our laboratory from human saliva and has been kinetically characterized using different aromatic substrates [35]. Also, the effect of some common substances frequently encountered by the enzyme in the oral cavity (such as ethanol, hydrogen peroxi

• br Materials and methods br Results and discussion

  2024-09-25

  

  Materials and methods Results and discussion First, we examined whether hypothalamic Akt-mediated signaling pathways are regulated postprandially in chickens. Refeeding significantly (P GMX1778 concentrations significantly increased in chicks after 1 h of refeeding (958 ± 245% of 24 h-fasting

• In particular we focused our attention

  2024-09-25

  

  In particular, we focused our attention on beta2 adrenergic receptors, since their commercial inhibitors are effective in lowering IOP, the primary indication of glaucoma. The hypotensive action of a commercial sequence of beta2 adrenergic receptor siRNA was tested in rabbits. The results confirmed

• Two cell surface trans membrane receptors

  2024-09-25

  

  Two cell-surface trans-membrane receptors have been identified for adiponectin, AdipoR1 and AdipoR2 [21], and adiponectin action is known to signal through these receptors and the docking protein APPL1 [22]. In muscle and liver cells, signal transduction involves the phosphorylation and activation o

• FRAX486 Curcumin is the principal natural polyphenol curcumi

  2024-09-25

  

  Curcumin is the principal natural polyphenol curcuminoid of turmeric (Curcuma longa) rhizome, a member of the ginger family (Zingiberaceae) [13]. Curcumin has a wide spectrum of therapeutic properties, and it has been shown to possess antioxidant, anti-inflammatory, anticancer, antiangiogenesis, che

• There has been growing interest over computational

  2024-09-25

  

  There has been growing interest over computational methods to predict the biological activity by chemical structure, so as to decide whether it Dextran sulfate sodium salt has objective qualities or not. In this contribution, the well-known method, which is called quantitative structure–activity re

• Compounds were profiled for their inhibitory

  2024-09-24

  

  Compounds – were profiled for their inhibitory activity against dipeptidyl peptidase-IV Activity and/or Structure Homologues (DASH) [e.g. DPP2, DPP8 and DPP9] and non-DASH [eg. post-proline cleaving enzyme (PPCE), neutral endopeptidase (NEP), aminopeptidase P (APP), aminopeptidase N (APN)] enzymes.

16238 records 76/1083 page Previous Next First page 上5页 7677787980 下5页 Last page