• Introduction br Coronary revascularization Ischemic

  2018-10-22

  

  Introduction Coronary revascularization Ischemic cardiomyopathy is caused by occlusive or obstructive coronary artery disease. Ischemic cardiomyopathy is now recognized as the most common cause of heart failure worldwide. It can be described in terms of three pathophysiological processes. (1) My

• The treatment of TEN poses a great challenge because

  2018-10-22

  

  The treatment of TEN poses a great challenge because of the rapid onset and progression of motilin receptor exfoliation with sepsis. Unfortunately, even with the advances in modern medicine, including improvements in intensive care, development of new dressing material and systemic therapies such as

• Complete immediate postoperative pain relief excellent outco

  2018-10-22

  

  Complete immediate postoperative pain relief (excellent outcome) was observed in 76.9% of the patients (n=20) and partial resolution (good outcome) in 3.8% (n=1). At 6 months postoperatively, 73.1% of the patients (n=19) reported an excellent outcome, whereas 7.7% (n=2) reported a good outcome. The

• We differentiated hESCs to the three primary germ layers

  2018-10-22

  

  We differentiated hESCs to the three primary germ layers in this system, identified extracellular biomarker profiles for each, and confirmed germ layer identity with gene expression analysis. A wide variety of extra- and intracellular markers have been previously utilized to identify each of the pri

• In relation to SSEA expression the differentiation

  2018-10-22

  

  In relation to SSEA3 expression, the ‘differentiation threshold’ may lie at different points along the linear path of differentiation (Fig. 4) depending on the cell line and the culture conditions used to propagate undifferentiated ES cells. In comparison to normal human ES cells, the adapted human

• It has not been reported

  2018-10-22

  

  It has not been reported whether behaviors of EPCs can be regulated by applied EFs. To be able to manipulate cellular behaviors of EPCs, and to direct EPCs to sites where angiogenesis is required, may have significant clinical implication in tissue engineering, and in controlling angiogenesis and ma

• br Methods br Results br Discussion We have developed

  2018-10-22

  

  Methods Results Discussion We have developed a serum-free method for the efficient generation of near pure populations of human ECs from hESCs and demonstrated the flexibility and utility of this system in identifying molecules that modulate endothelial phenotype. CD34+KDR+ hematovascular m

• It has been suggested that similarly to embryonic

  2018-10-22

  

  It has been suggested that similarly to embryonic stem orexin agonist (ESCs), stemness-related properties of some stromal stem/progenitor cells are supported by regulatory networks of transcription factors OCT4, SOX2 and NANOG (Greco et al., 2007; Ng and Surani, 2011; Park et al., 2012; Riekstina e

• Sorafenib Since the original group reported that VSELs

  2018-10-22

  

  Since the original group reported that VSELs can survive and differentiate to the hematopoietic lineage on OP9 cells, we sought to evaluate these candidate VSELs by the same assay, namely blood colony formation. When we cultured all the SYTOX-Blue-positive Sorafenib in the CD45−/intLin−SCA-1+ fract

• Our results can be explained

  2018-10-22

  

  Our results can be explained by the following model. During reprogramming, the de novo DNA methyltransferases (DNMTs) methylates not only the promoters of the somatic-specific genes that are undergoing reprogramming, but also the promoters of most cell-specific genes, even if they are not expressed

• Since mitochondria are a principal

  2018-10-22

  

  Since mitochondria are a principal source of ROS production, we also investigated whether PGC-1α-dependent mitochondrial changes result in altered ROS levels in cardiomyocytes. Although PGC-1α can induce the expression of antioxidant enzymes (St-Pierre et al., 2006), in this context the impact of ha

• The authors would like to

  2018-10-22

  

  The authors would like to thank Felecia Codrea and Jessica Scholes of the UCLA BSCRC FACS core, Suhua Feng of the UCLA BSCRC Sequencing core, and Tiasha Shafiq for immunostaining. This project was funded by NIH grant P01HD075795. Time-mated breeding was supported by NIH OD P51OD011092 (J.D.H.). The

• An approach that has shown promise

  2018-10-22

  

  An approach that has shown promise for answering these types of questions in other stem cell systems, and is becoming increasingly feasible with advanced computing power and improved tracking algorithms, is long-term in vitro imaging of individual stem and progenitor cells (Schroeder, 2011). Long-te

• In the last couple of years

  2018-10-20

  

  In the last couple of years several craniofacial NCSC-populations within the head were described. Such AZD-4547 were identified e.g. within the dental pulp and the periodontal ligament (Arnold et al., 2010; Waddington et al., 2009; Widera et al., 2007). Importantly, adult stem cells tend to transfor

• br Looking forward There has been considerable effort expend

  2018-10-20

  

  Looking forward There has been considerable effort expended on increasing awareness in the community about the risks of pursing stem cell treatment outside clinical trials (ASCC, 2009; ISSCR, 2010; Master and Caulfield, 2014; NSCFA, 2013). With patients rarely acknowledging risk other than financ

15913 records 1060/1061 page Previous Next First page 上5页 10561057105810591060 下5页 Last page