• hexokinase regulation Pilsicainide might increase hERG prote

  2019-05-16

  

  Pilsicainide might increase hERG proteins via facilitating the transcription of hERG from DNA to RNA or the translation of hERG RNA into hERG protein. Qualitative RT-PCR demonstrated the absence of an increase in hERG mRNA expression levels after pilsicainide treatment (Supplemental Fig. S2), indica

• br As the only methods available for dual

  2019-05-16

  

  As the only methods available for dual protection against pregnancy and sexually transmitted infections (STIs), male and female condoms have a vital role in sexual and reproductive health. Mags Beksinska and colleagues therefore are to be commended for their randomised crossover trial in this GSK

• The study by Wan Ling Wong and

  2019-05-16

  

  The study by Wan Ling Wong and colleagues examines the overall prevalence of age-related macular degeneration. In agreement with previous studies, Wong and colleagues have projected that 196 million people will be affected by age-related macular degeneration in 2020, increasing to 288 million by 204

• For many decades scientists have warned that

  2019-05-15

  

  For many decades, scientists have warned that human activity is pushing life on our planet beyond the point of no return. In the Earth\'s history there have been five mass extinction events, most recently the Cretaceous–Tertiary mass extinction that occurred almost 65 million years ago and was thou

• In Tara Mangal and colleagues report the

  2019-05-15

  

  In , Tara Mangal and colleagues report the results of their case-control study into the persistence of poliomyelitis in Nigeria, which identified low vaccine efficacy, poor vaccine coverage, suboptimum UM171 immunity, rejection and refusal of vaccine, and lack of awareness as issues responsible for

• br The Medical Education Partnership Initiative MEPI is

  2019-05-15

  

  The Medical Education Partnership Initiative (MEPI) is an innovative and potentially transformative 5-year programme, established by the US Government in 2010, to increase the number of doctors to meet crucial human resource needs in sub-Saharan Africa. MEPI allows African institutions that huge

• The very fact that providing a greater

  2019-05-15

  

  The very fact that providing a greater number of doses of IPTp-SP is incrementally effective, even in settings where the parasite is sensitive, also highlights the potential benefit of interventions using more effective drugs. This finding means there is either scope to improve clearance of existing

• br ALANISMO E IZQUIERDA UNIDA No plano pol tico o

  2019-05-15

  

  ALANISMO E IZQUIERDA UNIDA No plano político, o desmoronamento da iu está associado às ambiguidades com que se relacionou com a primeira força política do país neste momento, o apra e o presidente Alan García. Especificamente, o grupo em torno de Alfredo Barrantes acreditou em um cenário de alter

• Leptin synthesized in adipocytes is

  2019-05-15

  

  Leptin, synthesized in adipocytes, is a regulator of fat metabolism and reproduction [7]. The levels of leptin correlate with body fat mass and show a wide variation in individuals. In the bone marrow microenvironment, the leptin secreting adipocytes occupy a significant part [8]. Leptin stimulates

• Cardiac fibroblasts express various ion channels in particul

  2019-05-15

  

  Cardiac fibroblasts express various ion channels, in particular voltage-gated K phorbol myristate acetate and nonselective cation channels of the transient receptor potential (TRP) family . Both K and TRP channels are important determinants of fibroblast function, with TRP channels acting as Ca entr

• motilin receptor agonist Patients with syncope often suffer

  2019-05-15

  

  Patients with syncope often suffer secondary trauma. Major morbidities such as fractures and injuries from motor vehicle accidents have been reported in 6% of patients, whereas minor injuries such as lacerations and bruises have been reported in 29% [1]. Recurrent syncope was associated with fractur

• In another study Lopez and associates found

  2019-05-15

  

  In another study Lopez and associates found that patients with chronic heart failure receiving torsemide, a loop diuretic that inhibits the enzyme involved in the myocardial extracellular generation of collagen type I molecules (i.e., procollagen type I carboxy-terminal proteinase or PCP), had reduc

• Lo primero que designa el t

  2019-05-15

  

  Lo primero que designa el título es que Cc es, en dos niveles, el resultado de la acción performativa de PP. En un primer nivel, el autor Élmer Mendoza ha sufrido las consecuencias de la lectura y relectura de la novela de Rulfo, hasta el extremo de hacer un alto en el camino de su producción litera

• Seg n Patricia Fagen en su estudio cl sico sobre

  2019-05-14

  

  Según Patricia Fagen, en su estudio clásico sobre el exilio español, “un numero sorprendente de jóvenes participaron en el Movimiento 1959 y muchos más hubieran participado si hubiesen creído que había algo significativo con lo que hubieran podido contribuir”. El espíritu de ruptura con las disputas

• In normal embryogenesis the left cardinal vein

  2019-05-14

  

  In normal embryogenesis, the left cardinal vein involutes to form the ligament of Marshall, the right cardinal vein and the superior connection between the left and right cardinal veins persist to form the superior vena cava and the brachiocephalic vein, respectively. PLSVC is when involution of the

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