• Numerous studies have pointed to the DGAT reaction

  2021-05-10

  

  Numerous studies have pointed to the DGAT reaction being critical for TAG assembly and in several cases it has been shown to limit carbon flux from lipid precursors towards TAG accumulation [12]. Thus, in Brassica napus, the DGAT substrate, diacylglycerol (DAG), accumulates during periods of rapid l

• br Materials and methods br Results br Discussion This study

  2021-05-08

  

  Materials and methods Results Discussion This study demonstrates that various progestogens combined with E2 had different effects on breast cell growth. These effects had an inverse correlation with the changes of the PRA/PRB ratio. E2's antiapoptotic effects on MCF-7 acetylcholinesterase i

• AZ 10417808 br Results and discussion Analysis

  2021-05-08

  

  Results and discussion Analysis of experimental data indicates that the radon AZ 10417808 coefficient in OPC blended with RHA varies from 0.15 × 10−6 m2 s−1 for pure cement to 0.26 × 10−6 m2 s−1 for cement mixed with 50% RHA by weight. The value of diffusion coefficient first decreases in cement

• The third challenge is to understand the

  2021-05-08

  

  The third challenge is to understand the mechanisms of drug resistance. There are several different mechanisms of ES tumor to develop drug resistance. First, cancer stem cells are capable of proliferate and generate tumor cells with new sets of mutations which may harbor different protein targets [1

• Among RAS mutant tumors analyzed we found that the efficacy

  2021-05-08

  

  Among RAS mutant tumors analyzed, we found that the efficacy of either the SHP2 inhibitor SHP099, or combined MEK and SHP2 inhibition was best in those expressing RAS mutations at G12 (Figure 7B). Recent studies revealed that cellular RAS(G12C) activity depends on RTK-mediated nucleotide exchange, a

• As for the molecular mechanism Ferguson BD suggested that Ep

  2021-05-08

  

  As for the molecular mechanism, Ferguson BD suggested that EphB4/EphrinB2 stimulation induced topoisomerase I activity in small cell lung cancer cell lines. Treatment of MK2 inhibitor with EphrinB2/Fc induced topoisomerase activity as assessed by DNA relaxation in cells with high EphB4 expression l

• In the present study we first examined the in vivo

  2021-05-08

  

  In the present study, we first examined the in vivo and ex vivo effects of androgens on ep1 gap junction in the olfactory rosette of male B. sinensis. Thereafter, we cloned two different B.sinensis ar cDNAs and investigated their roles in the effects of 11-KT on ep1 expression. Material and meth

• Recent reports revealed that CSE affects the

  2021-05-08

  

  Recent reports revealed that CSE affects the endothelial cells of various tissues like kidney, liver, heart including ha tag peptide [26,30]. The damage of brain endothelial cells enhances the progress of cognitive dysfunction due to the accumulation of toxic free bio-radicals and activation of inf

• The imaging and biochemical data presented

  2021-05-08

  

  The imaging and biochemical data presented here demonstrated that in T cells, AEP played a specific function in cleaving Foxp3 but not Tbet. These results are in accordance with previous AEP studies where it has been shown that AEP substrates in part are not amenable to other protease activity. In a

• SB203580 Our approach including the characterization of

  2021-05-08

  

  Our approach, including the characterization of histone modifications in scarce NK subsets, allowed us to identify super-enhancers, which associate with genes endowing a given cell type with its unique identity (Hnisz et al., 2013). Especially intriguing were SEs with distinct activities in NK subse

• Autophagy is a degradation pathway existing in all eukaryoti

  2021-05-08

  

  Autophagy is a degradation pathway existing in all eukaryotic organisms. It is the main system for the degradation of bulk cytoplasmic components in cells (Feng et al., 2014), but it also plays a crucial role in other processes, as immunity (Wileman, 2013), mitochondrial (Dengjel and Abeliovich, 201

• The current study provides evidence for

  2021-05-08

  

  The current study provides evidence for a previously unknown role for DHODH as a growth/survival factor in KRAS mutant tumors. While many aspects of the link between DHODH inhibition and survival of KRAS mutant cells remain to be established, de novo pyrimidine biosynthesis appears to be a crucial p

• CYP enzymes have an important role in microsomal oxidase fun

  2021-05-08

  

  CYP450 PTC-209 synthesis have an important role in microsomal oxidase function across a broad range of taxa (Pakharukova et al., 2012). They are involved in metabolism and detoxification of both internally generated compounds and xenobiotics as the phase I metabolizing enzymes and play an important

• br Conflicts of interest br

  2021-05-07

  

  Conflicts of interest Acknowledgements This study was funded by Kuwait University Research Administration (Project MI03/10). Introduction Epidemiological, experimental and biologic plausibility support a cardioprotective effect of estrogens in women [1]. Indeed, women are protected until t

• Besides having a remarkable progestogenic effect an addition

  2021-05-07

  

  Besides having a remarkable progestogenic effect, an additional characteristic of DRSP is its strong antimineralocorticoid effect and antiandrogenic action [11]. DRSP is characterized by an antimineralocorticoid effect that is stronger when compared to progesterone. The decreasing synthesis of proge

16310 records 683/1088 page Previous Next First page 上5页 681682683684685 下5页 Last page