• In prostate cancer PCa glucose

  2021-09-23

  

  In prostate cancer (PCa), glucose metabolism plays a major role in progression [14]. Androgens can activate the metabolic regulator AMP-activated kinase (AMPK), promoting oxidative phosphorylation (OXPHOS) [15]. Besides, androgens increase GLUT1 [16], which overproduction has been described in the m

• Ability of D Ala GIP to attenuate the neurobehavioral

  2021-09-23

  

  Ability of D-Ala2GIP to attenuate the neurobehavioral sequelae in QA-induced Huntington's disease model by reduction in lipid peroxidation, restoration of endogenous antioxidants and decreased striatal monoamine levels is of potential interest. Considerable preclinical evidence now exists of the pot

• br Ghrelin and energy balance To characterize

  2021-09-23

  

  Ghrelin and tyramide synthesis balance To characterize the physiological role of ghrelin in energy homeostasis, ghsr−/− and ghrelin−/− mice were generated [33], [36], [41], [47]. Although ghrelin regulates the amplitude of episodic GH release, ghsr−/− mice were not dwarfs, and in fact appear ide

• But some experiments did not support the

  2021-09-23

  

  But some experiments did not support the antinociceptive role of GalR2 in peripheral locations beyond the DRG. The partial saphenous nerve ligation and the complete Freund's adjuvant model in the rats demonstrated that close intra-arterial infusion of galanin, but not galanin (2–11), reduced cooling

• Microglia after activation can show prominently

  2021-09-22

  

  Microglia after activation can show prominently pro-inflammatory but also anti-inflammatory characteristics [46]. Although the ageing process is not a pathological process, many of the age-associated changes resemble those observed under pathological conditions. An increase number of pro-inflammator

• Relative to the impact of moderate PAE on markers

  2021-09-22

  

  Relative to the impact of moderate PAE on markers of histaminergic neurotransmission, there were four salient observations from the studies reported here. First, it does not appear that moderate PAE affects the number of HDC-positive neurons in the tuberomammillary nucleus of the ventral hypothalamu

• Introduction Histamine Imidazolyl ethylamine is an important

  2021-09-22

  

  Introduction Histamine [2-(4-Imidazolyl)-ethylamine] is an important mediator of many physiological and pathological processes including inflammation, gastric Nicotine secretion, neuromodulation, regulation of immune function, cell proliferation and differentiation, among others. Histamine exerts

• To identify structurally novel autophagy inhibitors a medium

  2021-09-22

  

  To identify structurally novel autophagy inhibitors, a medium throughput screen of our in-house library of approximately 160,000 compounds was performed. In the screening assay, MCF7 atp citrate lyase stably transfected with eGFP-tagged light chain 3 (LC3), were employed, which can be detected by

• br sGC cGMP PKG pathway in

  2021-09-22

  

  sGC/cGMP/PKG pathway in regulation of platelet small GTPases All classical Rho family members of small GTPases including RhoA, Rac, Cdc42, some atypical Rho GTPases like RhoB, RhoF and RhoG, and also Ras family members N-Ras, K-Ras, Rap1A, Rap1B, Rap2A and Rap2B, and the Ras-related GTPases of th

• Recent work by Que et al

  2021-09-22

  

  Recent work by Que et al with mouse models implicates GSNOR in the cause of asthma. GSNOR is expressed in multiple cell types in the lung, including airway epithelial cells and infiltrating leukocytes. After exposure to ovalbumin, GSNOR activity increased in airway lining fluid, perhaps reflecting i

• Fibronectin protein level was not affected by DIF although

  2021-09-22

  

  Fibronectin protein level was not affected by DIF-1, although fibronectin has also been considered a canonical Wnt signaling pathway target gene product [39]. Thus, the canonical Wnt signaling pathway may not be critical for the regulation of the expression of fibronectin in malignant melanoma cells

• Introduction The onset of uterine labor is the culmination

  2021-09-22

  

  Introduction The onset of uterine labor is the culmination of a gradual uterine activation wherein physiological inflammation induces a common prolabor pathway characterized by increased myometrial contractility, weakening of fetal membrane integrity, and cervical ripening. Pathological proinflamma

• br Action of GPR in

  2021-09-22

  

  Action of GPR55 in metabolically active tissues In addition to being highly expressed by discrete brain regions, as described in Section 2, GPR55 is also expressed in a wide range of peripheral tissues, including spleen, adrenals and bone (Sawzdargo et al., 1999, Ryberg et al., 2007, Whyte et al.

• GLP is an intestinal peptide hormone

  2021-09-22

  

  GLP-1 is an intestinal peptide hormone that is released by the gut following ingestion of food, particularly γ-Linolenic Acid methyl ester and fats. Following its release, GLP-1 stimulates pancreatic β-cells to secrete insulin (Hirasawa et al., 2005, Covington et al., 2006). Originally, GLP-1 acted

• With the administration of OM fatty acids it has previously

  2021-09-22

  

  With the administration of OM3 fatty acids, it has previously been shown that the activation of GPR120 is linked to the secretion and circulating levels of the adipokine adiponectin [123] promoting anti-inflammation (downregulation of NF-κB) and insulin sensitivity [124]. Interestingly, Nrf2 also de

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