• Even though for almost years GnRH was considered

  2022-07-06

  

  Even though for almost 30 years GnRH was considered the main neuropeptide regulating gonadotropin release in vertebrates, Tsutsui et al. (2000) discovered, in the Japanese quail, Coturnix japonica, a hypothalamic neuropeptide that directly inhibits gonadotropin release, and thus named as gonadotropi

• However no reviews was focused on all the glutamate heterore

  2022-07-06

  

  However, no reviews was focused on all the glutamate heteroreceptor complexes and how to understand why some were formed and not others in the glutamate synapses and their extrasynaptic regions. These receptor complexes are present on the glutamate nerve terminals and the dendritic spines on which t

• Assuming thus a positive signal

  2022-07-06

  

  Assuming thus a positive signal for both GLUT1 and GLUT3 in our conditions, a more detailed explanation of the results observed through immunocytochemistry is needed. In this way, it must be reminded that syncytiotrophoblasts compose the outer layer of the trophoblast, are in direct contact with mat

• br Materials and methods br Results br Discussion

  2022-07-06

  

  Materials and methods Results Discussion The global pandemic of T2DM has mandated a search for new types of therapeutic agent and several long-acting analogs of naturally occurring incretins, particularly derivatives of GLP-1, have already been adopted in clinical practice [29]. This study

• br Secretase in inflammatory diseases Secretase appears to p

  2022-07-06

  

  γ-Secretase in inflammatory diseases γ-Secretase appears to play a more important role than previously recognized in inflammatory diseases. Studies have shown that mice partially deficient in PS genes (PS1+/− PS2−/−) develop an immune system deficit in late adulthood, such as ulcerated skin or a

• Considering the conformational preferences of the SRSRY sequ

  2022-07-05

  

  Considering the conformational preferences of the SRSRY sequence in the x-ray structures of soluble uPAR (SuPAR) [18], [19], [20], [50], [51], it is included in a quite flexible linker delimited by Cys76 and Cys95 residues. The SRSRY sequence adopts either α-turned or β-extended conformation. In any

• Recent research has focused on identifying key agonists

  2022-07-05

  

  Recent research has focused on identifying key agonists and receptors mediating nutrient-induced GLP-1 and insulin secretion. The long-chain fatty Glutathione (GSH/GSSG/Total) Fluorometric Assay Kit receptor GPR40 is the most abundant GPCR expressed in islet β cells and is also expressed on intesti

• We have expanded these studies by doing

  2022-07-05

  

  We have expanded these studies by doing EEG recording in the ET-1 model. Using this technique, we demonstrated that activation of either the ETA rgd peptide sale or the ETB receptor induces electrical seizures. ET-1 induced electrical seizures occurred in the presence of either the ETA receptor ant

• In various models histamine has been shown to

  2022-07-04

  

  In various models, histamine has been shown to induce chemotaxis. This was first appreciated over 40 years’ ago in studies with eosinophils (Clark et al., 1977). At that time, only histamine H1 and histamine H2 receptors were recognized and studies with ligands to these receptors indicated that neit

• In our study we found

  2022-07-04

  

  In our study, we found that HER2-mutant lung cancers occurred commonly in female patients with an advanced stage at time of diagnosis and in a relatively younger age group. Previously, Mazières et al. [8] obtained comparable epidemiological findings, including a median age of 60 years, a high propor

• Overall more males were HCV mono and co

  2022-07-04

  

  Overall, more males were HCV mono- and co-infected, though there was no significant age difference among groups and between men and women (all p>0.05). Almost all patients included in this study were over 40 years, in line with the period in which no HCV screening was performed in Brazilian blood b

• Acknowledgments Financial support from the National

  2022-07-04

  

  Acknowledgments Financial support from the National Natural Science Foundation of China (81730094, 81473262 and 81573299) is gratefully acknowledged. This project was also supported by the “111 Project” from the Ministry of Education of China, the State Administration of Foreign Expert Affairs of C

• Our inhibitor studies revealed the presence

  2022-07-04

  

  Our inhibitor studies revealed the presence of a signaling network triggered by dicarbonyl stress. Nevertheless, p38-MAPK activation was clearly necessary for NADPH-oxidase mediated production of ROS. This is consistent with data from other groups using different cell culture systems [37], [38], [39

• Betaine mg br Transporter based brain targeting nano DDS Dru

  2022-07-04

  

  Transporter-based brain-targeting nano-DDS Drug delivery to the central nervous system (CNS) is still challenging due to the bloodbrain barrier (BBB)53., 54.. The BBB is a natural defense barrier protecting the Betaine mg from harmful substances. Since only selected, neutral, lipophilic small mo

• br Materials and Methods br

  2022-07-04

  

  Materials and Methods Results All of the studied transporter genes were expressed at detectable levels in all the analyzed samples at mRNA level by means of applied rt-PCR method (CTaqz synthesis was observed for ABCC4, ABCC1, ABCG2, SLC22A3, and SLC22A18 (less than 10% of mean expression for

15562 records 388/1038 page Previous Next First page 上5页 386387388389390 下5页 Last page