• br Conclusions Our study confirms that

  2023-09-28

  

  Conclusions Our study confirms that N-terminal mutations can affect Aβ fibril and oligomer formation, despite lying outside the core amyloid region of Aβ. Of the three factors that may influence Aβ-mediated toxicity (primary structure of Aβ, assembly structure and cellular responses), our results

• The amino acids evaluated in

  2023-09-28

  

  The amino acids evaluated in this study represent proteinogenic (amino acids that are applied in the genetic code) or even essential ones (amino acids that cannot be synthesised by the organism and need to be taken up by nutrition). Tryptophan, phenylalanine, tyrosine, isoleucine, threonine and vali

• In the search for more specific

  2023-09-28

  

  In the search for more specific inhibitors of uptake2, Iversen and Salt (1970) speculated that steroids may potentiate the actions of catecholamines on vascular smooth muscle by inhibiting uptake2-mediated catecholamine clearance of the transmitters. They went on to demonstrate that a variety of ste

• While HTPCs are not immune cells they

  2023-09-28

  

  While HTPCs are not immune cells, they produce IL-6, MCP-1 and other immunologically relevant factors (Mayer et al., 2016). Our results demonstrated that epinephrine and phenylephrine increased the mRNA expression levels of COX-2, IL-6 and MCP-1 in HTPCs without affecting the mRNA expression level o

• ha141 Given these findings above we hypothesized that

  2023-09-28

  

  Given these findings above, we hypothesized that hypernociception produced by intra-amygdala 8-OH-DPAT is result of hyperpolarization in this area. This neuronal inhibition of the amygdaloid complex might result in an inactivation of crucial neurotransmitter systems of the descending inhibitory pain

• In the isolated right atrium activation of muscarinic

  2023-09-28

  

  In the isolated right atrium, activation of muscarinic receptors and adenosine receptors may block the generation of action potentials in the sinoatrial node, inducing cardiac arrest (Fig. 1, Fig. 2, Fig. 3, Fig. 4, Fig. 5) (Camara et al., 2015, Campbell et al., 1989). Physiologically, this conditio

• br Concluding Remarks The effects of point

  2023-09-28

  

  Concluding Remarks The effects of point mutations of the four ARs on ligand binding affinities, functional potencies, and efficacies constitute a valuable source of pharmacological information. We analyzed the existing data and mapped it on the collection of available AR crystal structures, allow

• br Conclusions The present data

  2023-09-28

  

  Conclusions The present data suggest that homeostatic balance of the cortical/hippocampal adenosinergic tone is necessary for normal working memory function and any deviation appears to impair performance – either as a consequence of A2AR under-activation when adenosine levels are reduced or due

• br Conflict of interest statement

  2023-09-27

  

  Conflict of interest statement Benign prostatic hyperplasia (BPH) is a highly complex process characterized by an increased number of epithelial and stromal topoisomerase i in the transition zone. , , Autopsy studies by McNeal detail the evolution of histological changes within these 2 cellular

• We demonstrate a role for

  2023-09-27

  

  We demonstrate a role for low oxygen to regulate ATX mRNA in hepatocyte-derived HuH7 Beauvericin and human liver slices, consistent with reports of increased ATX expression in a variety of tumours that are frequently hypoxic. Importantly, we show a positive association between elevated ATX mRNA lev

• The present study indicates elevated ATX activity as

  2023-09-27

  

  The present study indicates elevated ATX activity as a highly sensitive and specific biomarker to differentiate ICP from other pregnancy-related liver disorders or pruritic dermatoses. In Protein A/G to the current gold standard for diagnosis, total fasting serum bile salt levels, ATX appeared as a

• Of note core autophagy factors also play an

  2023-09-27

  

  Of note, core autophagy factors also play an important role during the infection of host cells by another type of picornavirus, namely, echovirus 7. ATG16L1 was found necessary for entry/internalization into Caco-2 polarized epithelial cells because the virus accumulated on the surface of ATG16L1-de

• Human leukemic blasts from both AML

  2023-09-27

  

  Human leukemic blasts from both AML and ALL patients demonstrated 5-, 12-, and 15-LOX expression [54]; however, using quantitative PCR, 5-LOX was much more prevalent than 15-LOX. When 15-HETE, 12-HETE, and LTB4 were tested for a direct effect on leukemic blasts, none induced apoptosis [54]. In contr

• The sequential behavioral approach used

  2023-09-27

  

  The sequential behavioral approach used in the present study reinforced the involvement of the BDNF/TRKB system in the effect of losartan. In mice with dampened BDNF expression, losartan was no longer able to exert antidepressant-like effects. Similar to what was observed after losartan treatment, t

• EDTA APP is a member of

  2023-09-27

  

  APP is a member of a conserved protein family that also includes amyloid precursor-like proteins 1 and 2 (APLP1, APLP2).8, 9, 10 The proteins in this family are type I single-pass transmembrane EDTA with receptor-like structural features but not entirely clear cellular functions.11, 12, 13, 14 Thes

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